Thyroid receptor-interacting protein 11

Definition:

Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.

References:

[1]. Anika Wehrle, et al. Hypomorphic mutations of TRIP11 cause odontochondrodysplasia. JCI Insight. 2019 Feb 7;4(3):e124701. [Content Brief]

[2]. C Infante, et al. GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. J Cell Biol. 1999 Apr 5;145(1):83-98. [Content Brief]

[3]. K H Chang, et al. A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9040-5. [Content Brief]

[4]. Peristera Roboti, et al. The golgin GMAP-210 is required for efficient membrane trafficking in the early secretory pathway. J Cell Sci. 2015 Apr 15;128(8):1595-606. [Content Brief]

[5]. Keisuke Sato, et al. Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210. Mol Biol Cell. 2015 Feb 1;26(3):537-53. [Content Brief]

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