Transcription factor COE4

Definition:

Transcription factor. Binds to specific sequence motif 5'-CCCNNG[GA]G-3' in regulatory elements of putative target immunoregulatory genes such as NKG7, GZMA, and TBX21. Positively modulates transcription of NKG7. May play a role in regulating FAS/CD95-mediated apoptosis in cytotoxic NK cells and T-cells, probably downstream of interleukin IL2 signaling.

References:

[1]. Satoshi Kubo, et al. Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2208522119. [Content Brief]

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