Transcription factor MafF

Definition:

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition.

References:

[1]. Xiaoxia Ye, et al. The novel human gene MIP functions as a co-activator of hMafF. Arch Biochem Biophys. 2006 May 15;449(1-2):87-93. [Content Brief]

[2]. O Johnsen, et al. Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. Nucleic Acids Res. 1996 Nov 1;24(21):4289-97. [Content Brief]

[3]. T Kimura, et al. Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. Biochem Biophys Res Commun. 1999 Oct 14;264(1):86-92. [Content Brief]

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