Transcription factor NF-E4

Definition:

Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.

References:

[1]. Wenlai Zhou, et al. The role of p22 NF-E4 in human globin gene switching. J Biol Chem. 2004 Jun 18;279(25):26227-32. [Content Brief]

[2]. W Zhou, et al. Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4. Mol Cell Biol. 2000 Oct;20(20):7662-72. [Content Brief]

[3]. Quan Zhao, et al. Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood. 2006 Mar 1;107(5):2138-45. [Content Brief]

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