Transcription initiation factor IIB

Definition:

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription.

References:

[1]. D Reinberg, et al. Factors involved in specific transcription in mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site. J Biol Chem. 1987 Mar 5;262(7):3322-30. [Content Brief]

[2]. Vladimir Gelev, et al. A new paradigm for transcription factor TFIIB functionality. Sci Rep. 2014 Jan 20;4:3664. [Content Brief]

[3]. D B Nikolov, et al. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature. 1995 Sep 14;377(6545):119-28. [Content Brief]

[4]. S Buratowski, et al. Functional domains of transcription factor TFIIB. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5633-7. [Content Brief]

[5]. Chu H Choi, et al. Transcription factor IIB acetylates itself to regulate transcription. Nature. 2003 Aug 21;424(6951):965-9. [Content Brief]

[6]. F T Tsai, et al. Structural basis of preinitiation complex assembly on human pol II promoters. EMBO J. 2000 Jan 4;19(1):25-36. [Content Brief]

[7]. Yuan He, et al. Near-atomic resolution visualization of human transcription promoter opening. Nature. 2016 May 19;533(7603):359-65. [Content Brief]

[8]. I Ha, et al. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature. 1991 Aug 22;352(6337):689-95. [Content Brief]

[9]. S Malik, et al. Potential RNA polymerase II-induced interactions of transcription factor TFIIB. Mol Cell Biol. 1993 Oct;13(10):6253-9. [Content Brief]

[10]. L Zawel, et al. Recycling of the general transcription factors during RNA polymerase II transcription. Genes Dev. 1995 Jun 15;9(12):1479-90. [Content Brief]

[11]. N H Ing, et al. Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem. 1992 Sep 5;267(25):17617-23. [Content Brief]

[12]. Wensheng Deng, et al. A core promoter element downstream of the TATA box that is recognized by TFIIB. Genes Dev. 2005 Oct 15;19(20):2418-23. [Content Brief]

[13]. A Barberis, et al. Delineation of two functional regions of transcription factor TFIIB. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5628-32. [Content Brief]

[14]. N A Hawkes, et al. The role of human TFIIB in transcription start site selection in vitro and in vivo. J Biol Chem. 1999 May 14;274(20):14337-43. [Content Brief]

[15]. S Malik, et al. Sequence of general transcription factor TFIIB and relationships to other initiation factors. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9553-7. [Content Brief]

[16]. K Hisatake, et al. Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity. Nature. 1993 Jun 24;363(6431):744-7. [Content Brief]

[17]. T Lagrange, et al. New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. Genes Dev. 1998 Jan 1;12(1):34-44. [Content Brief]

[18]. I Ha, et al. Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II. Genes Dev. 1993 Jun;7(6):1021-32. [Content Brief]

[19]. D Reinberg, et al. Factors involved in specific transcription by mammalian RNA polymerase II. Purification and functional analysis of initiation factors IIB and IIE. J Biol Chem. 1987 Mar 5;262(7):3310-21. [Content Brief]

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