Transcription initiation factor TFIID subunit 2

Definition:

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF2 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF1.

References:

[1]. Xizi Chen, et al. Structural insights into preinitiation complex assembly on core promoters. Science. 2021 Apr 30;372(6541):eaba8490. [Content Brief]

[2]. J Kaufmann, et al. CIF150, a human cofactor for transcription factor IID-dependent initiator function. Mol Cell Biol. 1998 Jan;18(1):233-9. [Content Brief]

[3]. E Martinez, et al. Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex. Mol Cell Biol. 1998 Nov;18(11):6571-83. [Content Brief]

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