Transforming growth factor beta-1-induced transcript 1 protein

Definition:

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.

References:

[1]. Marjet D Heitzer, et al. Hic-5/ARA55: a prostate stroma-specific AR coactivator. Steroids. 2007 Feb;72(2):218-20. [Content Brief]

[2]. N Fujimoto, et al. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. J Biol Chem. 1999 Mar 19;274(12):8316-21. [Content Brief]

[3]. Joo ri Kim-Kaneyama, et al. Transcriptional activation of the c-fos gene by a LIM protein, Hic-5. Biochem Biophys Res Commun. 2002 Dec 6;299(3):360-5. [Content Brief]

[4]. Matthew P Saelzler, et al. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. J Biol Chem. 2006 Jun 16;281(24):16821-32. [Content Brief]

[5]. Hui Wang, et al. Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. J Biol Chem. 2005 Feb 18;280(7):5154-62. [Content Brief]

[6]. Marjet D Heitzer, et al. Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells. Cancer Res. 2006 Jul 15;66(14):7326-33. [Content Brief]

[7]. M D Heitzer, et al. Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator. Mol Endocrinol. 2006 Jan;20(1):56-64. [Content Brief]

[8]. Vipul B Rathore, et al. Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J. 2007 Apr 15;403(2):275-81. [Content Brief]

[9]. Ana Marin D Carneiro, et al. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. J Biol Chem. 2006 Aug 25;281(34):24769-80. [Content Brief]

[10]. Xin Wang, et al. Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator. J Biol Chem. 2002 May 3;277(18):15426-31. [Content Brief]

[11]. Ana M Carneiro, et al. The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. J Neurosci. 2002 Aug 15;22(16):7045-54. [Content Brief]

[12]. N Nishiya, et al. Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase. Mol Cell Biol. 2001 Aug;21(16):5332-45. [Content Brief]

[13]. Jennifer Guerrero-Santoro, et al. Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation. J Cell Biochem. 2004 Jul 1;92(4):810-9. [Content Brief]

[14]. M Shibanuma, et al. Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1224-35. [Content Brief]

[15]. Mujib M Rahman, et al. Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5124-9. [Content Brief]

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