Transient receptor potential cation channel subfamily M member 3

Definition:

Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. In addition, forms heteromultimeric ion channels with TRPM1 which are permeable for calcium and zinc ions.

References:

[1]. Ning Lee, et al. Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). J Biol Chem. 2003 Jun 6;278(23):20890-7. [Content Brief]

[2]. Christian Grimm, et al. Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem. 2003 Jun 13;278(24):21493-501. [Content Brief]

[3]. Sachar Lambert, et al. Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions. J Biol Chem. 2011 Apr 8;286(14):12221-33. [Content Brief]

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