Transient receptor potential cation channel subfamily M member 7

Definition:

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

References:

[1]. Carsten Schmitz, et al. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell. 2003 Jul 25;114(2):191-200. [Content Brief]

[2]. Maxim V Dorovkov, et al. Phosphorylation of annexin I by TRPM7 channel-kinase. J Biol Chem. 2004 Dec 3;279(49):50643-6. [Content Brief]

[3]. Zhenyu Cai, et al. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol. 2014 Jan;16(1):55-65. [Content Brief]

[4]. Rosa Vargas-Poussou, et al. Possible role for rare TRPM7 variants in patients with hypomagnesemia with secondary hypocalcemia. Nephrol Dial Transplant. 2022 May 13;gfac182. [Content Brief]

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