Trinucleotide repeat-containing gene 6A protein

Definition:

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.

References:

[1]. Jidong Liu, et al. A role for the P-body component GW182 in microRNA function. Nat Cell Biol. 2005 Dec;7(12):1261-6. [Content Brief]

[2]. Andrew Jakymiw, et al. Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol. 2005 Dec;7(12):1267-74. [Content Brief]

[3]. Shangli Lian, et al. Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. Mol Biol Cell. 2007 Sep;18(9):3375-87. [Content Brief]

[4]. Jakob T Zipprich, et al. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA. 2009 May;15(5):781-93. [Content Brief]

[5]. Motoaki Wakiyama, et al. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev. 2007 Aug 1;21(15):1857-62. [Content Brief]

[6]. Songqing Li, et al. Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing. J Cell Sci. 2008 Dec 15;121(Pt 24):4134-44. [Content Brief]

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