tRNA-dihydrouridine

Definition:

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

References:

[1]. Tatsuya Kato, et al. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Res. 2005 Jul 1;65(13):5638-46. [Content Brief]

[2]. Wei Dai, et al. Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Nat Chem Biol. 2021 Nov;17(11):1178-1187. [Content Brief]

[3]. Charles Bou-Nader, et al. Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. Biochemistry. 2018 Sep 18;57(37):5407-5414. [Content Brief]

[4]. Charles Bou-Nader, et al. An extended dsRBD is required for post-transcriptional modification in human tRNAs. Nucleic Acids Res. 2015 Oct 30;43(19):9446-56. [Content Brief]

[5]. Megan Mittelstadt, et al. Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR. Nucleic Acids Res. 2008 Feb;36(3):998-1008. [Content Brief]

[6]. Olivier Finet, et al. Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Mol Cell. 2022 Jan 20;82(2):404-419.e9. [Content Brief]

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