tRNA dimethylallyltransferase

Definition:

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA). TRIT1 is therefore required for selenoprotein expression.

References:

[1]. A Golovko, et al. Cloning of a human tRNA isopentenyl transferase. Gene. 2000 Nov 27;258(1-2):85-93. [Content Brief]

[2]. Eva Schöller, et al. Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs. Mol Cell. 2021 Dec 2;81(23):4810-4825.e12. [Content Brief]

[3]. Tek N Lamichhane, et al. Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor. Mol Cell Biol. 2013 Dec;33(24):4900-8. [Content Brief]

[4]. John W Yarham, et al. Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA. PLoS Genet. 2014 Jun 5;10(6):e1004424. [Content Brief]

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