tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial

Definition:

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

References:

[1]. Jing-Bo Zhou, et al. Molecular basis for t6A modification in human mitochondria. Nucleic Acids Res. 2020 Apr 6;48(6):3181-3194. [Content Brief]

[2]. Huan Lin, et al. CO2-sensitive tRNA modification associated with human mitochondrial disease. Nat Commun. 2018 May 14;9(1):1875. [Content Brief]

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