tRNA pseudouridine synthase Pus10

Definition:

Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.

References:

[1]. Sun-Young Park, et al. DOBI is cleaved by caspases during TRAIL-induced apoptotic cell death. BMB Rep. 2009 Aug 31;42(8):511-5. [Content Brief]

[2]. Jinghui Song, et al. Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. Nat Chem Biol. 2020 Feb;16(2):160-169. [Content Brief]

[3]. Pedro Aza-Blanc, et al. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol Cell. 2003 Sep;12(3):627-37. [Content Brief]

[4]. Shaoni Mukhopadhyay, et al. Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA. RNA. 2021 Jan;27(1):66-79. [Content Brief]

[5]. Manisha Deogharia, et al. The human ortholog of archaeal Pus10 produces pseudouridine 54 in select tRNAs where its recognition sequence contains a modified residue. RNA. 2019 Mar;25(3):336-351. [Content Brief]

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