Trypsin-3

Definition:

Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.

References:

[1]. Gergely Katona, et al. Crystal structure reveals basis for the inhibitor resistance of human brain trypsin. J Mol Biol. 2002 Feb 1;315(5):1209-18. [Content Brief]

[2]. Richárd Szmola, et al. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. J Biol Chem. 2003 Dec 5;278(49):48580-9. [Content Brief]

[3]. Moh'd A Salameh, et al. Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin. J Biol Chem. 2008 Feb 15;283(7):4115-23. [Content Brief]

[4]. C N Nyaruhucha, et al. Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance. J Biol Chem. 1997 Apr 18;272(16):10573-8. [Content Brief]

[5]. Olumide Kayode, et al. An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis. J Biol Chem. 2016 Dec 16;291(51):26304-26319. [Content Brief]

[6]. Devon Pendlebury, et al. Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin. J Biol Chem. 2014 Nov 21;289(47):32783-97. [Content Brief]

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