Tumor necrosis factor receptor superfamily member 19L

Definition:

May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation.

References:

[1]. John K Cusick, et al. RELT induces cellular death in HEK 293 epithelial cells. Cell Immunol. 2010;261(1):1-8. [Content Brief]

[2]. Jung-Wook Kim, et al. Mutations in RELT cause autosomal recessive amelogenesis imperfecta. Clin Genet. 2019 Mar;95(3):375-383. [Content Brief]

[3]. Tara C Polek, et al. The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Biochem Biophys Res Commun. 2006 Apr 28;343(1):125-34. [Content Brief]

[4]. Pachai Moua, et al. RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1. Biochem Biophys Res Commun. 2017 Sep 9;491(1):25-32. [Content Brief]

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