2. Biology Dictionary
  3. Tumornecrosisfactor receptor-related factors (TRAFs)

Tumornecrosisfactor receptor-related factors (TRAFs)

Definition:

Tumor necrosis factor receptor-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development.

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