Tyrosine-protein phosphatase non-receptor type 12

Definition:

Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.

References:

[1]. Hui Li, et al. Crystal Structure and Substrate Specificity of PTPN12. Cell Rep. 2016 May 10;15(6):1345-58. [Content Brief]

[2]. David Taieb, et al. ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity. Cancer Res. 2008 Jun 15;68(12):4588-96. [Content Brief]

[3]. Surasri Nandan Sahu, et al. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2288-96. [Content Brief]

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