2. Cell Cycle/DNA Damage
  3. Wee1
  4. Bosutinib isomer

Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively.

For research use only. We do not sell to patients.

Bosutinib isomer Chemical Structure

Bosutinib isomer Chemical Structure

CAS No. : 1391063-17-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Bosutinib isomer:

Bosutinib isomer Related Antibodies

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Description

Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively[1].

In Vitro

Bosutinib isomer (0-10 μM) shows the high growth inhibitory potential against HEK293T, MM1.S, and MDA-MB-231 cells, with IC50 values of 1.6 ± 0.19, 3.9 ± 0.50, and 1.8 ± 0.061 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bosutinib isomer Related Antibodies
Molecular Weight

530.45

Formula

C26H29Cl2N5O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=C(NC2=CC(Cl)=C(OC)C(Cl)=C2)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (94.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8852 mL 9.4260 mL 18.8519 mL
5 mM 0.3770 mL 1.8852 mL 3.7704 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8852 mL 9.4260 mL 18.8519 mL 47.1298 mL
5 mM 0.3770 mL 1.8852 mL 3.7704 mL 9.4260 mL
10 mM 0.1885 mL 0.9426 mL 1.8852 mL 4.7130 mL
15 mM 0.1257 mL 0.6284 mL 1.2568 mL 3.1420 mL
20 mM 0.0943 mL 0.4713 mL 0.9426 mL 2.3565 mL
25 mM 0.0754 mL 0.3770 mL 0.7541 mL 1.8852 mL
30 mM 0.0628 mL 0.3142 mL 0.6284 mL 1.5710 mL
40 mM 0.0471 mL 0.2356 mL 0.4713 mL 1.1782 mL
50 mM 0.0377 mL 0.1885 mL 0.3770 mL 0.9426 mL
60 mM 0.0314 mL 0.1571 mL 0.3142 mL 0.7855 mL
80 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5891 mL
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Bosutinib isomer Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bosutinib isomer1391063-17-4Wee1Inhibitorinhibitorinhibit

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