2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. CB2 receptor agonist 2

CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.

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CB2 receptor agonist 2 Chemical Structure

CB2 receptor agonist 2 Chemical Structure

CAS No. : 1314230-75-5

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CB2 receptor agonist 2 Related Antibodies

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Description

CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2[1].

IC50 & Target[1]

CB2

8.5 nM (Ki)

In Vitro

CB2 receptor agonist 2 (compound 4g) (1  μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB2 receptor agonist 2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Hep-G2 (Human hepatoblastoma) cells
Concentration: 1  μM
Incubation Time: 72 hours
Result: Exhibited very low or no cytotoxicity to Hep-G2 cells.
In Vivo

CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Formalin injection induces a biphasic stereotypical nocifensive behavior in mice[1]
Dosage: Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour
Administration: Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)
Result: Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.
Molecular Weight

488.62

Formula

C30H36N2O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CN(CCCCC)C2=C(C1=O)C=C(C3=CC=CO3)C=C2OC)NC45CC6CC(C5)CC(C4)C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 30 mg/mL (61.40 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0466 mL 10.2329 mL 20.4658 mL
5 mM 0.4093 mL 2.0466 mL 4.0932 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.0466 mL 10.2329 mL 20.4658 mL 51.1645 mL
5 mM 0.4093 mL 2.0466 mL 4.0932 mL 10.2329 mL
10 mM 0.2047 mL 1.0233 mL 2.0466 mL 5.1165 mL
15 mM 0.1364 mL 0.6822 mL 1.3644 mL 3.4110 mL
20 mM 0.1023 mL 0.5116 mL 1.0233 mL 2.5582 mL
25 mM 0.0819 mL 0.4093 mL 0.8186 mL 2.0466 mL
30 mM 0.0682 mL 0.3411 mL 0.6822 mL 1.7055 mL
40 mM 0.0512 mL 0.2558 mL 0.5116 mL 1.2791 mL
50 mM 0.0409 mL 0.2047 mL 0.4093 mL 1.0233 mL
60 mM 0.0341 mL 0.1705 mL 0.3411 mL 0.8527 mL
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CB2 receptor agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB2 receptor agonist 21314230-75-5Cannabinoid Receptoraffinityselectivityselective human hepatoblastomacannabinoidInhibitorinhibitorinhibit

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