2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis Bcl-2 Family Caspase
  4. CDK1/2/4-IN-1

CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research.

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CDK1/2/4-IN-1 Chemical Structure

CDK1/2/4-IN-1 Chemical Structure

CAS No. : 2414633-49-9

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CDK1/2/4-IN-1 Related Antibodies

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Description

CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].

IC50 & Target[1]

CDK2

0.78 (IC50)

CDK4

0.87 (IC50)

CDK1

1.47 (IC50)

Caspase 3

 

Bax

 

Bcl-2

 

In Vitro

CDK1/2/4-IN-1 (compound 3a) (0.01-100 µM; 24 hours) has antitumor activity in cancer cell lines[1].
CDK1/2/4-IN-1 (compound 3a) (1.39 µM; 24 hours) induces apoptosis and arrests cell cycle at G2/M phase in A549 cells[1].
CDK1/2/4-IN-1 (compound 3a) (1.39 µM; A549 cells) induces up-regulation of the expression of Bax, caspases-3 and p53, and increases the ratio of Bcl-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK1/2/4-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Liver cancer cell line (HepG-2), lung cancer cell line (A549) and breast cancer cell line (MCF-7)
Concentration: 0.01, 0.1, 1.0, 10, 100 µM
Incubation Time: 24 hours
Result: Displayed cytotoxic activity with IC50 values of 1.56, 1.39 and 1.97 µM for HepG-2, A549 and MCF-7, respectively.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 1.39 µM
Incubation Time: 24 hours
Result: Increased G2/M phase by 2.6 folds compared with the control cells.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 1.39 µM
Incubation Time: 24 hours
Result: Increased the overall percentage of the apoptotic cells.
Molecular Weight

288.36

Formula

C15H16N2O2S
CAS No.
SMILES

O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK1/2/4-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1/2/4-IN-12414633-49-9CDKApoptosisBcl-2 FamilyCaspaseCyclin dependent kinaseapoptosisBclcaspaseanticancerInhibitorinhibitorinhibit

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