Chitin synthase inhibitor 4

Name: Chitin synthase inhibitor 4
Brand: MedChemExpress
SKU: HY-150686
Rating: 4.5 (1 reviews)

Cat. No.: HY-150686 Purity: 99.48%: FAQs
Data Sheet SDS COA Handling Instructions

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Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture.

For research use only. We do not sell to patients.

Chitin synthase inhibitor 4 Chemical Structure

CAS No. : 2755847-31-3

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 181	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 181	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture^[1].

In Vitro

Chitin synthase inhibitor 4 shows good antifungal activities against V. mali and S. sclerotiorum with EC₅₀ values of 0.71 and 2.47 μg/mL, respectively^[1].
Chitin synthase inhibitor 4 (50 μg/mL) displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7%, respectively^[1].
Chitin synthase inhibitor 4 (1 μg/mL) blocks the hyphae growth, results abnormal growth, with inducing cell content decreasing, cell wall degradation, and plasmolysis^[1].
Chitin synthase inhibitor 4 (50 μM; 3 h) exhibits inhibition against chitin synthase and polyoxin D with inhibition rates of 68.08% and 63.84%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity ^[1].
Chitin synthase inhibitor 4 has low acute toxicity, with no carcinogenic and mutagenic toxicity risk^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat with Salmonella typhimurium^[1]
Dosage:	As Acute Oral Toxicity for Chemicals-Acute Toxic Class Method
Administration:	Oral gavage
Result:	Showed acute toxicity of 3.58 as toxicity grading standard, and negative carcinogenic toxicity, negative mutagenic toxicity.

Molecular Weight

346.36

Formula

C₂₀H₁₅FN₄O

CAS No.

2755847-31-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=CC=C1OC2=NC=NC(N3CCCC4=C3C=CC=C4)=C2F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (288.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8872 mL	14.4358 mL	28.8717 mL
5 mM	0.5774 mL	2.8872 mL	5.7743 mL
10 mM	0.2887 mL	1.4436 mL	2.8872 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.48%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (143 KB) RP-HPLC (151 KB) LCMS (227 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. Synthesis, Antifungal Activity, and 3D-QASR of Novel 1,2,3,4-Tetrahydroquinoline Derivatives Containing a Pyrimidine Ether Scaffold as Chitin Synthase Inhibitors. J Agric Food Chem. 2022 Jul 21. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8872 mL	14.4358 mL	28.8717 mL	72.1792 mL
	5 mM	0.5774 mL	2.8872 mL	5.7743 mL	14.4358 mL
	10 mM	0.2887 mL	1.4436 mL	2.8872 mL	7.2179 mL
	15 mM	0.1925 mL	0.9624 mL	1.9248 mL	4.8119 mL
	20 mM	0.1444 mL	0.7218 mL	1.4436 mL	3.6090 mL
	25 mM	0.1155 mL	0.5774 mL	1.1549 mL	2.8872 mL
	30 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4060 mL
	40 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8045 mL
	50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4436 mL
	60 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2030 mL
	80 mM	0.0361 mL	0.1804 mL	0.3609 mL	0.9022 mL
	100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL