CL 5343 (Synonyms: 5-Amino-1,3,4-thiadiazole-2-sulfonamide)

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CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B). CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells.

For research use only. We do not sell to patients.

CL 5343 Chemical Structure

CAS No. : 14949-00-9

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 295	In-stock	Estimated Time of Arrival: December 31
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Description	CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B). CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells^[1]^[2].
Molecular Weight	180.21
Formula	C₂H₄N₄O₂S₂
CAS No.	14949-00-9
Appearance	Solid
SMILES	O=S(C1=NN=C(N)S1)(N)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Pesando JM, et al. Proton magnetic resonance studies of carbonic anhydrase. III. Binding of sulfonamides. Biochemistry. 1975;14(4):689-693. [Content Brief] [2]. Pérez-Herrero E, et al. The reversed intra-and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers[J]. Acta Pharmaceutica Sinica B, 2021, 11(8): 2243-2264. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL 534314949-00-95-Amino-1,3,4-thiadiazole-2-sulfonamideCL5343CL-5343Carbonic AnhydraseCarbonate dehydrataseSKRC52CA9 ligandmaytansinoidInhibitorinhibitorinhibit

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CL 5343 (Synonyms: 5-Amino-1,3,4-thiadiazole-2-sulfonamide)

CL 5343 Related Antibodies

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Biological Activity

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References

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