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Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo.

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Clofibride Chemical Structure

Clofibride Chemical Structure

CAS No. : 26717-47-5

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Clofibride Related Antibodies

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Description

Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo[1].

In Vivo

Clofibride (oral, 400; 500 and 1000 mg/kg; single) can rapidly and massively resorb and hydrolys into 4chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD rats, male and female beagles, olive baboon monkeys[1]
Dosage: 400, 1000 mg/kg (rats); 500 mg/kg (dogs and monkeys)
Administration: oral, single
Result: HMB is rapidly metabolized and the half-life of CPIB, the main active metabolite, in the serum is about 12 h in the rat, 43 +9 h in the dog and 6t 1 h in the baboon.
Molecular Weight

327.80

Formula

C16H22ClNO4
CAS No.
SMILES

CC(OC1=CC=C(C=C1)Cl)(C(OCCCC(N(C)C)=O)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Clofibride Related Classifications

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Keywords:

Clofibride26717-47-5Othersoralhypolipaemicpchlorophenoxyisobutyrichypocholesterolaemichypotriglyceridaemic4-chlorophenoxyisobutyric acid (CPIB)4-hydroxy-N-dimethylbutyramide (HMB)Inhibitorinhibitorinhibit

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