1. GPCR/G Protein
  2. GnRH Receptor
  3. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH  (Synonyms: Surfagon)

Cat. No.: HY-P0048
Handling Instructions

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH Chemical Structure

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH Chemical Structure

CAS No. : 52435-06-0

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Description

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3].

In Vitro

(Des-Gly10, D-Ala6, Pro-NHEt9)-LHRH as internal standard for leuprorelin acetate[1]
(1) Add 10 μL 200 ng/mL (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH solution to 100 μL plasma sample.
(2) Add ice-cold acetonitrile to solution in (1) in two batches (500 µL each time).
(3) Stir at 2500 rpm for 10 min.
(4) Centrifugation at 12500 rpm (4℃) for 10min.
(5) Transfer the supernatant into a centrifuge tube, dried under nitrogen gas at 35℃, and finally add 100 µL 0.1% formic acid in water/acetonitrile: 90/10 (v/v) solution.
(6) The Thermo Scientific Vanquish UPLC system is connected to the Thermo Scientific Orbitrap Explorer 480 mass spectrometer. Using the Waters Acquity UPLC HSS T3 column (2.1 × 100 mm, 1.8 µm) separation at a temperature of 40℃.
(7) The mobile phase A is 0.1% formic acid in water, and the mobile phase B is 0.1% formic acid in acetonitrile solution. The gradient starts at 95% mobile phase A, decreases to 10% over 5 min, and then remains constant for 0.5 min. At 6 min, the column returned to 95% mobile phase A and is rebalanced for 2 min. The flow rate was 0.3 mL/min and the injection volume is 20 µL.
(8) The sample is ionized by 3500V electric spray. In positive-ion mode, m/z 605.3275 is leuprolide acetate, and m/z 584.3052 is the internal standard. Data are analyzed by Xcalibur software (version 4.4).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 µg/kg; i.p.; single dose) significantly increases anxiety behavior in adult male rats with and without gonadectomy[2].
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 µg; single dose) improves the fertility of cows after fertilization and prevents embryo death when combined with Ainil (30 µL/kg)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1167.32

Formula

C56H78N16O12

CAS No.
Sequence

{Pyr}-His-Trp-Ser-Tyr-{d-Ala}-Leu-Arg-Pro-NHEt

Sequence Shortening

{Pyr}-HWSY-{d-Ala}-LRP-NHEt

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH
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