2. Immunology/Inflammation
  3. Interleukin Related
  4. Efineptakin alfa

Efineptakin alfa  (Synonyms: NT-17)

Cat. No.: HY-P99908

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Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. Efineptakin alfa supports the proliferation and survival CD4+ and CD8+ cells in both human and mice. Efineptakin alfa can be used for glioblastoma research.

For research use only. We do not sell to patients.

Efineptakin alfa Chemical Structure

Efineptakin alfa Chemical Structure

CAS No. : 2026634-47-7

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Efineptakin alfa Related Antibodies

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Description

Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. Efineptakin alfa supports the proliferation and survival CD4+ and CD8+ cells in both human and mice. Efineptakin alfa can be used for glioblastoma research[1].

IC50 & Target

IL7R

 

In Vivo

Efineptakin alfa (10 mg/kg, IM, single) combined with SLC-3010 (1.8 mg/kg, IV, single) inhibits tumor growth in MC38-bearing mice[1].
Efineptakin alfa (10 mg/kg) mitigates RT-related lymphopenia, increases cytotoxic CD8 T lymphocytes systemically and in the tumor, and improves survival in orthotopic glioma-bearing mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice bearing intracranial tumors (GL261 or CT2A)[1]
Dosage: 10 mg/kg
Administration: On the final day of RT (radiotherapy, 1.8 Gy/day × 5 days) completion
Result: Increased T lymphocytes in the lymph nodes, thymus, and spleen, enhanced IFNγ production, and decreased Tregs in the tumor which was associated with a significant increase in survival. Enhanced central memory and effector memory CD8 T cells in lymphoid organs and tumor. Decreased progenitor cells in the bone marrow.
Clinical Trial
CAS No.
SMILES

[Efineptakin alfa]
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Efineptakin alfa Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efineptakin alfa2026634-47-7NT-17NT17NT 17Interleukin RelatedILorthotopic gliomaglioblastomaCD8+ T cellsrhIL-7-hyFcInhibitorinhibitorinhibit

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