2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR kinase inhibitor 1

EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity.

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EGFR kinase inhibitor 1 Chemical Structure

EGFR kinase inhibitor 1 Chemical Structure

CAS No. : 2413958-04-8

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EGFR kinase inhibitor 1 Related Antibodies

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Description

EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity[1].

IC50 & Target[1]

EGFR (WT)

37 nM (IC50)

EGFRL858R/T790M

1.7 nM (IC50)

EGFRL858R/T790M/C797S

>300 nM (IC50)

In Vitro

EGFR kinase inhibitor 1 (compound 17i) (72 h) shows antiproliferative activity with IC50s of 4.17, 0.052 µM for A549, H1975 cells, respectively[1].
EGFR kinase inhibitor 1 (0.05, 0.5, 5 µM; 48 h) induces apoptosis in a dose-dependent manner[1].
EGFR kinase inhibitor 1 (4, 20, 100 nM; 48 h) induces cell cycle arrest at G0/G1-phase[1].
EGFR kinase inhibitor 1 (0.5 μM; 0, 24, 48 h) inhibits the motility of the H1975 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR kinase inhibitor 1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, H1975 cells
Concentration:
Incubation Time: 72 h
Result: Showed antiproliferation activity with IC50s of 4.17, 0.052 µM for A549, H1975 cells, respectively.

Apoptosis Analysis[1]

Cell Line: H1975 cells
Concentration: 0.05, 0.5, 5 µM
Incubation Time: 48 h
Result: Induced apoptosis in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: H1975 cells
Concentration: 4, 20, 100 nM
Incubation Time: 48 h
Result: Induced cell cycle arrest at G0/G1-phase with the percentage of G0/G1-phase cells increased from 42.93% to 60.52% at 4 nM, 70.39% at 20 nM and 80.03% at 100 nM.
Molecular Weight

521.61

Formula

C30H31N7O2
CAS No.
SMILES

C=CC(NC1=C(C=C(C(NC2=NC(C3=CN(C4=C3C=CC=C4)C)=CC=N2)=C1)OC)N5C=CC=C5CN(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR kinase inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR kinase inhibitor 12413958-04-8EGFR kinase inhibitor1EGFR kinase inhibitor-1EGFRApoptosisEpidermal growth factor receptorErbB-1HER1antiproliferativeanti-tumorapoptosisG0/G1-phaseH1975 cellscell motilityInhibitorinhibitorinhibit

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EGFR kinase inhibitor 1
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