2. Anti-infection
  3. HIV
  4. Enfuvirtide acetate

Enfuvirtide acetate  (Synonyms: T20 acetate; DP178 acetate)

Cat. No.: HY-P0052A Purity: 97.22%
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Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Enfuvirtide acetate Chemical Structure

Enfuvirtide acetate Chemical Structure

CAS No. : 914454-00-5

Size Price Stock Quantity
5 mg USD 72 In-stock
10 mg USD 108 In-stock
25 mg USD 228 In-stock
50 mg USD 408 In-stock
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200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Enfuvirtide acetate:

Enfuvirtide acetate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

IC50 & Target

HIV fusion[1]
In Vitro

A cell-cell fusion assay reveals that the effective concentration for achieving 50% inhibition (IC50) of Enfuvirtide is 23 ± 6 nM[2]. IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz, Indinavir, and Enfuvirtide) significantly inhibita the expression of HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3) also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz, Indinavir, and Enfuvirtide[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enfuvirtide acetate Related Antibodies
In Vivo

Enfuvirtide has a T1/2 of 3.8 h[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

4551.93

Formula

C206H305N51O66
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
Sequence Shortening

Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (21.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2 mg/mL (0.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2197 mL 1.0984 mL 2.1969 mL
5 mM 0.0439 mL 0.2197 mL 0.4394 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2197 mL 1.0984 mL 2.1969 mL 5.4922 mL
5 mM 0.0439 mL 0.2197 mL 0.4394 mL 1.0984 mL
10 mM 0.0220 mL 0.1098 mL 0.2197 mL 0.5492 mL
15 mM 0.0146 mL 0.0732 mL 0.1465 mL 0.3661 mL
20 mM 0.0110 mL 0.0549 mL 0.1098 mL 0.2746 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Enfuvirtide acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enfuvirtide914454-00-5T20DP178T 20T-20DP 178DP-178HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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