2. Metabolic Enzyme/Protease Apoptosis
  3. Fatty Acid Synthase (FASN) Apoptosis
  4. Fasnall

Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities.

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Fasnall Chemical Structure

Fasnall Chemical Structure

CAS No. : 929978-58-5

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Fasnall Related Antibodies

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Description

Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1].

IC50 & Target

IC50: 3.71 μM (human purified FASN activity)[1]
In Vitro

Fasnall potently blocks both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells[1].
Fasnall (50 μM; 24-120 h) inhibits proliferation in breast cancer cell lines[1].
Fasnall (25-100 μM; 24 h) induces apoptosis in HER2+ breast cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fasnall Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF7, MDA-MB-468, BT474 and SKBR3 cells
Concentration: 50 μM
Incubation Time: 24 h, 48 h, 72 h, 96 h, 120 h
Result: Inhibited the proliferation of aggressive cell lines, but showed lower activity in the non-tumorigenic cell line MCF10A.

Apoptosis Analysis[1]

Cell Line: MCF7, MDA-MB-468, BT474 and SKBR3 cells
Concentration: 25 μM, 50 μM , 75 μM, 100 μM
Incubation Time: 24 h
Result: Induced caspase-3 and caspase-7 activation.
In Vivo

Fasnall (15 mg/kg, intraperitoneally, twice weekly; 3 weeks) shows potent anti-tumor activity in MMTV-Neu model of HER2+ breast cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female MMTV-NEU mice bearing HER2+ breast cancer cells[1]
Dosage: 15 mg/kg
Administration: i.p.; twice weekly; 3 weeks
Result: Reduced tumor volume, and increased the median survival of the MMTV-Neu mice to 63 days.
Molecular Weight

338.47

Formula

C19H22N4S
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

CC1=C(C2=C(N=CN=C2S1)NC3CN(CC3)CC4=CC=CC=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References
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Fasnall Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fasnall929978-58-5Fatty Acid Synthase (FASN)ApoptosisFASN catalyzesthiophenopyrimidineanti-tumor activityapoptosis inducerInhibitorinhibitorinhibit

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