2. Apoptosis Autophagy
  3. Autophagy Apoptosis
  4. FB49

FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells.

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FB49 Chemical Structure

FB49 Chemical Structure

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5 mg USD 520 In-stock
10 mg USD 810 In-stock
25 mg USD 1600 Get quote
50 mg USD 2400 Get quote
100 mg USD 3600 Get quote
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Based on 1 publication(s) in Google Scholar

FB49 Related Antibodies

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Description

FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells[1].

Molecular Weight

378.40

Formula

C17H18N2O6S
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(C(C)C(N1CCOCC1)=O)C/2=O)SC2=C/C3=CC=CC(O)=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (264.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6427 mL 13.2135 mL 26.4271 mL
5 mM 0.5285 mL 2.6427 mL 5.2854 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6427 mL 13.2135 mL 26.4271 mL 66.0677 mL
5 mM 0.5285 mL 2.6427 mL 5.2854 mL 13.2135 mL
10 mM 0.2643 mL 1.3214 mL 2.6427 mL 6.6068 mL
15 mM 0.1762 mL 0.8809 mL 1.7618 mL 4.4045 mL
20 mM 0.1321 mL 0.6607 mL 1.3214 mL 3.3034 mL
25 mM 0.1057 mL 0.5285 mL 1.0571 mL 2.6427 mL
30 mM 0.0881 mL 0.4405 mL 0.8809 mL 2.2023 mL
40 mM 0.0661 mL 0.3303 mL 0.6607 mL 1.6517 mL
50 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3214 mL
60 mM 0.0440 mL 0.2202 mL 0.4405 mL 1.1011 mL
80 mM 0.0330 mL 0.1652 mL 0.3303 mL 0.8258 mL
100 mM 0.0264 mL 0.1321 mL 0.2643 mL 0.6607 mL
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FB49 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FB49FB 49FB-49AutophagyApoptosisHD-MB03BAG3apoptosisautophagyRS4A549Inhibitorinhibitorinhibit

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