POLR3F - RNA polymerase III subunit F Gene

Homo sapiens

Also known as C34; RPC6; RPC39; IMD101

Gene ID: 10621 | Gene type: protein coding

About POLR3F

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,467,390-18,484,646 (from NCBI)

This gene has 22 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in brain (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues.

Summary

The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

POLR3F Products(3)

mRNA	Protein	Name
NM_001282526.2	NP_001269455.1	DNA-directed RNA polymerase III subunit RPC6 isoform 2
NM_001410821.1	NP_001397750.1	DNA-directed RNA polymerase III subunit RPC6 isoform 3
NM_006466.4	NP_006457.2	DNA-directed RNA polymerase III subunit RPC6 isoform 1

POLR3F Protein Structure

RNA_pol_Rpc34

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerase III subunit RPC6

RNA polymerase III C39 subunit

Related Diseases

Diseases

Alias

Immunodeficiency 101

IMD101

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy	Ppcd
Maumenee Corneal Dystrophy	Posterior Polymorphous Corneal Dystrophy 1
PPCD1	Corneal Dystrophy, Hereditary Polymorphous Posterior
Corneal Endothelial Dystrophy 1, Autosomal Dominant	Schlichting Dystrophy
Ched1	Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly
Ched1, Formerly	Hereditary Polymorphus Posterior Corneal Dystrophy
Posterior Polymorphous Dystrophy	Hereditary Polymorphous Posterior Corneal Dystrophy
Dystrophy, Corneal, Posterior Polymorphous	Dystrophy, Corneal, Posterior Polymorphous, Type 1
Polymorphous Corneal Dystrophy	Corneal Endothelial Dystrophy 2

Hypomyelinating Leukoencephalopathy

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10859	POLR3F Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	POLR3F	VGNC	VGNC:64294
Macaca mulatta	POLR3F	VGNC	VGNC:76032
Bos taurus	POLR3F	VGNC	VGNC:33150
Canis familiaris	POLR3F	VGNC	VGNC:44804
Rattus norvegicus	POLR3F	RGD	RGD:1306428
Mus musculus	POLR3F	MGD	MGI:1924086

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