TMED1 - transmembrane p24 trafficking protein 1 Gene

Homo sapiens

Also known as Tp24; p24g1; Il1rl1l; IL1RL1LG

Gene ID: 11018 | Gene type: protein coding

About TMED1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,832,067-10,836,212 (from NCBI)

This gene has 7 transcripts (splice variants), 256 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 10.9), kidney (RPKM 10.9) and 25 other tissues.

Summary

This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

TMED1 Products(1)

mRNA	Protein	Name
NM_006858.4	NP_006849.1	transmembrane emp24 domain-containing protein 1 precursor

TMED1 Protein Structure

EMP24_GP25L

0
100
200
227 a.a.

Protein Preferred Names

Protein Names

transmembrane emp24 domain-containing protein 1

IL1RL1-binding protein

Recombinant TMED1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72445	TMED1 Protein, Human (171a.a, HEK293, Fc)	Q13445 (A24-N194)	≥95%
HY-P77239	TMED1 Protein, Human (194a.a, HEK293, Fc)	Q13445 (M1-N194)	≥95%
HY-P77240	TMED1 Protein, Human (HEK293, His)	Q13445 (A24-N194)	≥95%

Related Diseases

Diseases

Alias

Anemia, Congenital Dyserythropoietic, Type Iiia

Congenital Dyserythropoietic Anemia, Type Iii	Cdan3
Congenital Dyserythropoietic Anemia Type Iii	Cda Iii
Congenital Dyserythropoietic Anemia Type 3	CDAN3A
Dyserythropoietic Anemia, Congenital, Type Iiia	Cda, Type Iiia
Anemia, Congenital Dyserythropoietic, Type Iii	Anemia With Multinucleated Erythroblasts
Cda Type 3	Cda Type Iii
Dyserythropoietic Anemia, Congenital Type 3	Cda, Type Iii
Erythroreticulosis, Hereditary Benign	Anaemia With Multinucleated Erythroblasts
Congenital Dyserythropoietic Anaemia Type 3	Congenital Dyserythropoietic Anaemia Type Iii
Hereditary Benign Erythroreticulosis	Anemia, Congenital Dyserythropoietic, 3a
Anemia With Multinucleated Erythroblasts Erythroreticulosis, Hereditary Benign

Cystoisosporiasis

Isosporiasis	Infection By Isospora Belli And Isospora Hominis
Isosporosis	Infection By Isospora Belli Or Isospora Hominis
Isospora Belli Or Hominis Infection	Coccidial Infestation
Coccidiosis	Coccidial Dysentery
Intestinal Coccidiosis Nos

Anemia, Congenital Dyserythropoietic, Type Iv

CDAN4	Congenital Dyserythropoietic Anemia Type Iv
Congenital Dyserythropoietic Anemia Type 4	Cda Iv
Cda Due To Klf1 Mutation	Cda Type 4
Cda Type Iv	Congenital Dyserythropoietic Anemia Due To Klf1 Mutation
Cda, Type Iv	Dyserythropoietic Anemia, Congenital, Type Iv
Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation	Congenital Dyserythropoietic Anaemia Type 4
Congenital Dyserythropoietic Anaemia Type Iv	Anemia, Congenital Dyserythropoietic, 4
Anemia, Dyserythropoietic Congenital, Type Iv	Anemia, Dyserythropoietic, Congenital, Type Iv

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14634	TMED1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMED1	RGD	RGD:1311679
Macaca mulatta	TMED1	VGNC	VGNC:79071
Bos taurus	TMED1	VGNC	VGNC:35934
Felis catus	TMED1	VGNC	VGNC:80736
Canis familiaris	TMED1	VGNC	VGNC:47436
Mus musculus	TMED1	MGD	MGI:106201
Others	TMED1	NCBI

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