VTI1A - vesicle transport through interaction with t-SNAREs 1A Gene

Homo sapiens

Also known as MMDS3; MVti1; VTI1RP2; Vti1-rp2

Gene ID: 143187 | Gene type: protein coding

About VTI1A

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:112,446,988-112,855,368 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 62 phenotypes. Ubiquitous expression in brain (RPKM 1.6), bone marrow (RPKM 1.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

VTI1A Products(8)

mRNA	Protein	Name
NM_001318203.2	NP_001305132.1	vesicle transport through interaction with t-SNAREs homolog 1A isoform a
NM_001318205.2	NP_001305134.1	vesicle transport through interaction with t-SNAREs homolog 1A isoform c
NM_001365710.2	NP_001352639.1	vesicle transport through interaction with t-SNAREs homolog 1A isoform d
NM_001365711.1	NP_001352640.1	vesicle transport through interaction with t-SNAREs homolog 1A isoform e
NM_001365712.1	NP_001352641.1	vesicle transport through interaction with t-SNAREs homolog 1A isoform f
NM_001365713.1	NP_001352642.1	vesicle transport through interaction with t-SNAREs homolog 1A isoform f
NM_001365714.1	NP_001352643.1	vesicle transport through interaction with t-SNAREs homolog 1A isoform g
NM_145206.4	NP_660207.2	vesicle transport through interaction with t-SNAREs homolog 1A isoform b

VTI1A Protein Structure

V-SNARE

V-SNARE_C

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

vesicle transport through interaction with t-SNAREs homolog 1A

SNARE Vti1a-beta protein

Recombinant VTI1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76700	VTI1A Protein, Human (HEK293, His)	Q96AJ9-2 (M1-R187)	≥95%
HY-P76701	VTI1A Protein, Human (HEK293, Fc)	Q96AJ9-2 (M1-R187)	≥95%

Related Diseases

Diseases

Alias

Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts	Mlc
Van Der Knaap Disease	Lvm
Leukoencephalopathy With Swelling And Cysts	Megalencephaly-Cystic Leukodystrophy
Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome	Infantile Leukoencephalopathy And Megalencephaly
Leukoencephalopathy With Swelling And A Discrepantly Mild Course	Vacuolating Leukoencephalopathy
Megalencephalic Leukodystrophy	Megalencephaly-Cystic Leukodystrophy Syndrome
Van Der Knaap Syndrome	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Pseudohypoparathyroidism, Type Ib

Pseudohypoparathyroidism Type 1b	PHP1B
Pseudohypoparathyroidism Ib	Pseudohypoparathyroidism Type Ib
Php Ib	Pseudohypoparathyroidism 1b

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15722	VTI1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VTI1A	VGNC	VGNC:48316
Mus musculus	VTI1A	MGD	MGI:1855699
Bos taurus	VTI1A	VGNC	VGNC:55979
Rattus norvegicus	VTI1A	RGD	RGD:621490
Others	VTI1A	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.