Tlr7 - toll-like receptor 7 Gene

Mus musculus

Gene ID: 170743 | Gene type: protein coding

About Tlr7

Chromosome X: 166,087,925-166,113,554 reverse strand.GRCm39:CM001013.3

This gene has 6 transcripts (splice variants), 197 orthologues, 23 paralogues and is associated with 14 phenotypes. Low expression observed in reference dataset.

Summary

Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; response to virus; and Toll-like Receptor 7 signaling pathway. Acts upstream of or within positive regulation of interleukin-6 production and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Tlr7 Products(5)

mRNA	Protein	Name
NM_001290757.1	NP_001277686.1	toll-like receptor 7 isoform a precursor
NM_001290756.1	NP_001277685.1	toll-like receptor 7 isoform a precursor
NM_001290755.1	NP_001277684.1	toll-like receptor 7 isoform a precursor
NM_001290758.1	NP_001277687.1	toll-like receptor 7 isoform b
NM_133211.4	NP_573474.1	toll-like receptor 7 isoform a precursor

Tlr7 Protein Structure

PRK15370

LRR_RI

PLN00113

LRR_RI

PCC

TIR

0
200
400
600
800
1050 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 7

Toll like receptor 7

Recombinant Tlr7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79405	TLR7 Protein, Mouse (His)	P58681 (N275-F444)	≥95%

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0180	Imiquimod	Agonist	99.96%	Yes
HY-B1370	Hydroxychloroquine sulfate	Inhibitor	99.99%	Yes
HY-B0180A	Imiquimod hydrochloride	Agonist	99.77%	Yes
HY-B0180B	Imiquimod maleate	Agonist	99.25%	Yes
HY-B1370B	(R)-Hydroxychloroquine	Inhibitor	/	Unkown
HY-B1370A	(S)-Hydroxychloroquine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-134581	Enpatoran	Inhibitor	99.77%	Phase 2
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.33%	Phase 2
HY-118250	GSK2245035	Agonist	99.85%	Phase 2
HY-111269	AZD8848	Agonist	98.08%	Phase 2
HY-100176	PF-4878691	Agonist	99.89%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.98%	Phase 1
HY-111786	LHC-165	Agonist	≥98.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (52)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124603	AT791	Inhibitor	98.77%	Unkown
HY-N0201	Atractylenolide I	Antagonist	99.87%	Unkown
HY-128799	CL097	Agonist	99.89%	Unkown
HY-103697A	Gardiquimod diTFA	Agonist	≥99.0%	Unkown
HY-135905	CL264	Inhibitor	98.63%	Unkown
HY-108472	Loxoribine	Agonist	99.64%	Yes
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	Unkown
HY-12756A	E6446 dihydrochloride	Antagonist	99.96%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	97.33%	Unkown
HY-103697	Gardiquimod	Agonist	99.57%	Unkown
HY-110120	DSR-6434	Agonist	99.55%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-150736	ODN 20844	Inhibitor	96.52%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.04%	Unkown
HY-10018	Toll-like receptor modulator	Modulator	99.36%	Unkown
HY-115400	1V209	Agonist	99.67%	Unkown
HY-131945	CU-115	Antagonist	99.55%	Unkown
HY-117602	TLR7 agonist 3	Agonist	99.80%	Unkown
HY-153071	TLR7 agonist 6	Agonist	98.08%	Unkown
HY-111358	TLR7 agonist 1	Agonist	98.95%	Unkown
HY-150158	TMX-201		≥95.0%	Unkown
HY-13740S	Resiquimod-d5	Agonist	99.84%	Unkown
HY-145961	TLR7 agonist 4	Agonist	98.87%	Unkown
HY-111582	BBIQ	Agonist	99.85%	Unkown
HY-110207	SM-324405	Agonist	98.24%	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.51%	Unkown
HY-150744	ODN 24888	Inhibitor	93.10%	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	/	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	/	Unkown
HY-12756	E6446	Antagonist	≥98.0%	Unkown
HY-139575	Guretolimod	Agonist	/	Unkown
HY-147215	UC-1V150	Agonist	/	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-160229	ssRNA40 sodium	Activator	93.25%	Unkown
HY-157793	SMU-L11	Agonist	/	Unkown
HY-163398	TLR7-IN-1	Inhibitor	/	Unkown
HY-B1370R	Hydroxychloroquine sulfate (Standard)	Inhibitor	/	Unkown
HY-153073	TLR7 agonist 8	Agonist	/	Unkown
HY-156175	TLR7 agonist 14	Agonist	/	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown
HY-153072	TLR7 agonist 7	Agonist	/	Unkown
HY-158694	TLR7 agonist 20	Agonist	/	Unkown
HY-162115	TLR7 agonist 17	Agonist	/	Unkown
HY-153070	TLR7 agonist 5	Agonist	/	Unkown
HY-160227A	ORN 06 sodium	Activator	/	Unkown
HY-156174	E104	Inhibitor	/	Unkown
HY-152726	TLR7 agonist 9	Agonist	/	Unkown
HY-111582G	BBIQ (GMP)	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr7	NCBI	NCBI:51284

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