THSD7A - thrombospondin type 1 domain containing 7A Gene

Homo sapiens

Gene ID: 221981 | Gene type: protein coding

About THSD7A

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:11,370,365-11,832,198 (from NCBI)

This gene has 4 transcripts (splice variants), 276 orthologues and 3 paralogues. Broad expression in kidney (RPKM 4.1), placenta (RPKM 2.1) and 17 other tissues.

Summary

The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) Integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

THSD7A Products(1)

mRNA	Protein	Name
NM_015204.3	NP_056019.1	thrombospondin type-1 domain-containing protein 7A precursor

THSD7A Protein Structure

TSP_1

0
300
600
900
1200
1500
1657 a.a.

Protein Preferred Names

Protein Names

thrombospondin type-1 domain-containing protein 7A

thrombospondin, type I, domain containing 7A

Recombinant THSD7A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78044	THSD7A Protein, Human (HEK293, His)	Q9UPZ6 (A48-W1607)	≥95%

Related Diseases

Diseases

Alias

Membranous Nephropathy

Membranous Glomerulonephritis	Glomerulonephritis, Membranous
Idiopathic Membranous Nephropathy	Idiopathic Membranous Glomerulonephritis
MBNP	Membranous Nephropathy, Susceptibility To
Extramembranous Glomerulonephritis	Mgn
Membranous Gn	Primary Membranous Glomerulonephritis
Primary Membranous Nephropathy	Nephropathy Membranous

Bronchiectasis 3

Kimura Disease

Kimura'S Disease	Eosinophilic Lymphogranuloma
Eosinophilic Granuloma Of Soft Tissue	Eosinophilic Hyperplastic Lymphogranuloma
Eosinophilic Lymphofollicular Granuloma	Eosinophilic Lymphofolliculosis

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Histiocytoid Hemangioma

Angiolymphoid Hyperplasia With Eosinophilia	Epithelioid Haemangioma
Epithelioid Hemangioma

Goodpasture Syndrome

Anti-Glomerular Basement Membrane Disease	Anti-Gbm Disease
Pulmonary Renal Syndrome	Anti-Glomerular Basement Membrane Antibody Disease
Glomerulonephritis - Pulmonary Hemorrhage	Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage
Anti-Gbm Syndrome	Goodpasture'S Syndrome
Anti-Basement Membrane Glomerulonephritis

Autoimmune Disease Of Urogenital Tract

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis	Dense Deposit Disease
Membranoproliferative Glomerulonephritis Type 2	Primary Membranoproliferative Glomerulonephritis
Mesangiocapillary Glomerulonephritis, Type Ii	Glomerulonephritis, Membranoproliferative
Chronic Glomerulonephritis, Lobular	Lobular Glomerulonephritis
Ddd	Glomerulonephritis Membranoproliferative Type 2
Mpgn 2	Membranoproliferative Glomerulonephritis Type Ii
Mesangiocapillary Glomerulonephritis Type 2	Mpgn
Primary Mpgn	Glomerulonephritis Membranoproliferative
Membranoproliferative Glomerulonephritis, Type Ii

Lipoid Nephrosis

Minimal Change Disease	Minimal Change Glomerulonephritis
Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis	Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome
Idiopathic Minimal Change Nephrotic Syndrome	Mcns
Minimal Change Glomerulopathy	Minimal Change Nephrotic Syndrome
Nephrotic Syndrome Minimal Change	Nephrosis, Lipoid
Glomerulonephritis, Minimal Change	Nephrotic Syndrome, Minimal Change

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14505	THSD7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	THSD7A	RGD	RGD:1566201
Bos taurus	THSD7A	VGNC	VGNC:35850
Mus musculus	THSD7A	MGD	MGI:2685683
Canis familiaris	THSD7A	VGNC	VGNC:47358
Macaca mulatta	THSD7A	VGNC	VGNC:79347
Felis catus	THSD7A	VGNC	VGNC:66176
Others	THSD7A	NCBI

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