2. Gene
  3. Cdk13 - cyclin-dependent kinase 13 Gene

Cdk13 - cyclin-dependent kinase 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cdc2l5

Gene ID: 306998 | Gene type: protein coding

About Cdk13

Primary_assembly 17: 47,251,163-47,341,721 forward strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 207 orthologues, 24 paralogues and is associated with 9 phenotypes. Biased expression in Thymus (RPKM 25.), Spleen (RPKM 226.6) and 9 other tissues.

Summary

Predicted to enable cyclin binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in RNA metabolic process; hemopoiesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of stem cell differentiation. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be part of cyclin K-CDK13 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder. Orthologous to human CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Apr 2022]

Cdk13 Products(2)

mRNA Protein Name
NM_001271295.2 NP_001258224.2 cyclin-dependent kinase 13 isoform 1
NM_001271296.2 NP_001258225.2 cyclin-dependent kinase 13 isoform 2

Cdk13 Protein Structure

STKc_CDK12

STKc_CDK12: cd07864 (696 - 997)

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  • 1527 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 13

cell division cycle 2-like 5 (cholinesterase-related cell division controller)

cell division protein kinase 13

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 98.78% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 98.37% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.45% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader / Unkown
HY-158170 CDK7-IN-28 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk13 NCBI NCBI:8621