TREML1 - triggering receptor expressed on myeloid cells like 1 Gene

Homo sapiens

Also known as TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3

Gene ID: 340205 | Gene type: protein coding

About TREML1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,149,260-41,155,403 (from NCBI)

This gene has 4 transcripts (splice variants), 95 orthologues and 13 paralogues. Biased expression in bone marrow (RPKM 1.9), lymph node (RPKM 1.7) and 10 other tissues.

Summary

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

TREML1 Products(3)

mRNA	Protein	Name
NM_001271807.1	NP_001258736.1	trem-like transcript 1 protein isoform b precursor
NM_001271808.1	NP_001258737.1	trem-like transcript 1 protein isoform c precursor
NM_178174.4	NP_835468.1	trem-like transcript 1 protein isoform a precursor

TREML1 Protein Structure

V-set

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

trem-like transcript 1 protein

triggering receptor expressed on myeloid cells-like protein 1

Recombinant TREML1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71382	TREML1 Protein, Human (147a.a, HEK293, His)	Q86YW5 (Q16-P162)	≥95%
HY-P77237	TREML1 Protein, Human (162a.a, HEK293, His)	Q86YW5 (M1-P162)	≥95%
HY-P701054	TREML1 Protein, Human (147a.a, HEK293, hFc)	XP_016866312.1 (Q16-P162)	≥95%

Related Diseases

Diseases

Alias

Gray Platelet Syndrome

Platelet Alpha-Granule Deficiency	GPS
Bdplt4	Bleeding Disorder, Platelet-Type, 4
Grey Platelet Syndrome	Platelet-Type Bleeding Disorder 4
Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins	Deficient Alpha Granule Syndrome
Platelet Alpha Granule Deficiency	Platelet Granule Defect
Alpha Storage Pool Deficiency	Bleeding Disorder Platelet-Type 4

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Shwartzman Phenomenon

Shwartzman Reaction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15004	TREML1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TREML1	RGD	RGD:1565175
Macaca mulatta	TREML1	VGNC	VGNC:79250
Mus musculus	TREML1	MGD	MGI:1918576
Bos taurus	TREML1	VGNC	VGNC:36300
Felis catus	TREML1	VGNC	VGNC:66520
Others	TREML1	NCBI

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