1. Gene
  2. AK3 - adenylate kinase 3 Gene

AK3 - adenylate kinase 3 Gene

Homo sapiens

Also known as AK6; FIX; AK3L1; AKL3L; AKL3L1

Gene ID: 50808 | Gene type: protein coding

About AK3

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:4,709,556-4,742,043 (from NCBI)

This gene has 4 transcripts (splice variants), 230 orthologues and 9 paralogues. Ubiquitous expression in liver (RPKM 32.7), fat (RPKM 26.9) and 25 other tissues.

Summary

The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

AK3 Products(5)

mRNA Protein Name
NM_001199852.2 NP_001186781.1 GTP:AMP phosphotransferase AK3, mitochondrial isoform b
NM_001199853.2 NP_001186782.1 GTP:AMP phosphotransferase AK3, mitochondrial isoform c
NM_001199855.2 NP_001186784.1 GTP:AMP phosphotransferase AK3, mitochondrial isoform c
NM_001199856.2 NP_001186785.1 GTP:AMP phosphotransferase AK3, mitochondrial isoform c
NM_016282.4 NP_057366.2 GTP:AMP phosphotransferase AK3, mitochondrial isoform a

AK3 Protein Structure

ADK

ADK: Adenylate kinase (12 - 191)

ADK_lid

ADK_lid: Adenylate kinase, active site lid (128 - 163)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

GTP:AMP phosphotransferase AK3, mitochondrial

GTP:AMP phosphotransferase, mitochondrial

Recombinant AK3 Proteins

Cat. No. Product Name Accession Purity
HY-P71645 AK3 Protein, Human (Myc, His) Q9UIJ7-1 (M1-P227) ≥95%

Related Diseases

Diseases Alias
Reticular Dysgenesis

Severe Combined Immunodeficiency With Leukopenia

De Vaal Disease

Congenital Aleukia

Aleukocytosis

Hematopoietic Hypoplasia, Generalized

Reticular Dysgenesia

Devaal Disease

Rd

Ak2 Deficiency

Congenital Aleukocytosis

Generalized Hematopoietic Hypoplasia

Scid With Leukopenia

RDYS

Orofacial Cleft 8

OFC8

Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8

Non-Syndromic Cleft Lip/Palate 8

Non-Syndromic Cleft Lip With Or Without Cleft Palate 8

Orofacial Cleft, Type 8

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis

German Type Amyloidosis

Familial Renal Amyloidosis

Amyloidosis Viii

Amyloidosis, 3 Or More Types

Familial Visceral Amyloidosis

Familial Amyloid Nephropathy

Hereditary Amyloid Nephropathy

Amyloidosis, Familial Renal

Amyloidosis, Systemic Nonneuropathic

Amyloidosis Familial Visceral

Amyloidosis 8

Amyloidosis, Ostertag Type

Hereditary Amyloidosis With Primary Renal Involvement

Hereditary Renal Amyloidosis

Renal Amyloidosis

Amyloidosis, Renal

Systemic Nonneuropathic Amyloidosis

Amyloidosis Familial Renal

Amyloidosis Systemic Nonneuropathic

Hereditary Amyloidosis With Primary Renal Involement

AMYL8

Systemic Non-Neuropathic Amyloidosis

Amyloid Nephropathy

Schizophrenia 1

SCZD1

Schizophrenia Susceptibility Locus, Chromosome 5-Related

Schizophrenia 1 With Or Without An Affective Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus AK3 VGNC VGNC:25772
Mus musculus AK3 MGD MGI:1860835
Macaca mulatta AK3 VGNC VGNC:69623
Felis catus AK3 VGNC VGNC:102897
Rattus norvegicus AK3 RGD RGD:619885
Others AK3 NCBI