2. Gene
  3. CDK16 - cyclin dependent kinase 16 Gene

CDK16 - cyclin dependent kinase 16 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE

Gene ID: 5127 | Gene type: protein coding

About CDK16

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,218,303-47,229,997 (from NCBI)

This gene has 22 transcripts (splice variants), 174 orthologues, 26 paralogues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 14.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

CDK16 Products(15)

mRNA Protein Name
XM_047442152.1 XP_047298108.1 cyclin-dependent kinase 16 isoform X5
NM_006201.5 NP_006192.1 cyclin-dependent kinase 16 isoform 1
XM_011543922.2 XP_011542224.1 cyclin-dependent kinase 16 isoform X4
XM_011543926.2 XP_011542228.1 cyclin-dependent kinase 16 isoform X7
NM_001170460.2 NP_001163931.1 cyclin-dependent kinase 16 isoform 3
NM_033018.4 NP_148978.2 cyclin-dependent kinase 16 isoform 2
XM_011543920.4 XP_011542222.1 cyclin-dependent kinase 16 isoform X1
XM_011543923.3 XP_011542225.1 cyclin-dependent kinase 16 isoform X6
XM_011543925.3 XP_011542227.1 cyclin-dependent kinase 16 isoform X7
NM_033019.1
XM_047442153.1 XP_047298109.1 cyclin-dependent kinase 16 isoform X8
XM_017029569.2 XP_016885058.1 cyclin-dependent kinase 16 isoform X3
XM_011543924.3 XP_011542226.1 cyclin-dependent kinase 16 isoform X7
XM_047442154.1 XP_047298110.1 cyclin-dependent kinase 16 isoform X9
XM_011543921.2 XP_011542223.1 cyclin-dependent kinase 16 isoform X2

CDK16 Protein Structure

Pkinase

Pkinase: Protein kinase domain (166 - 446)

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  • 496 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 16

PCTAIRE-motif protein kinase 1

cell division protein kinase 16

serine/threonine-protein kinase PCTAIRE-1

testis secretory sperm-binding protein Li 224n

Recombinant CDK16 Proteins

Cat. No. Product Name Accession Purity
HY-P76536 PCTAIRE1 Protein, Human (sf9, GST) Q00536-1 (M1-F496) ≥95%

Related Diseases

Diseases Alias
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-148063 DB0614 98.80% Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown
HY-160213 JA397 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDK16 RGD RGD:620584
Felis catus CDK16 VGNC VGNC:68735
Mus musculus CDK16 MGD MGI:97516
Bos taurus CDK16 VGNC VGNC:27119
Macaca mulatta CDK16 VGNC VGNC:71160
Canis familiaris CDK16 VGNC VGNC:39048
Others CDK16 NCBI