ARL8B - ADP ribosylation factor like GTPase 8B Gene

Homo sapiens

Also known as Gie1; ARL10C

Gene ID: 55207 | Gene type: protein coding

About ARL8B

Cytogenetic location: 3p26.1 Genomic coordinates (GRCh38): 3:5,122,292-5,180,911 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 48.8), thyroid (RPKM 43.1) and 25 other tissues.

Summary

Enables guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; lysosomal transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Colocalizes with lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARL8B Products(1)

mRNA	Protein	Name
NM_018184.3	NP_060654.1	ADP-ribosylation factor-like protein 8B

ARL8B Protein Structure

Arf

0
100
186 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 8B

ADP-ribosylation factor-like 10C

Related Diseases

Diseases

Alias

Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS	Sedaghatian Chondrodysplasia
Spondylometaphyseal Dysplasia Sedaghatian Type	Congenital Lethal Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia, Congenital Lethal	Lethal Metaphyseal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00999	ARL8B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARL8B	VGNC	VGNC:84238
Rattus norvegicus	ARL8B	RGD	RGD:1562830
Mus musculus	ARL8B	MGD	MGI:1914416
Canis familiaris	ARL8B	VGNC	VGNC:38122
Felis catus	ARL8B	VGNC	VGNC:59930
Bos taurus	ARL8B	VGNC	VGNC:26154

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