RAC2 - Rac family small GTPase 2 Gene

Homo sapiens

Also known as Gx; EN-7; IMD73A; IMD73B; IMD73C; HSPC022; p21-Rac2

Gene ID: 5880 | Gene type: protein coding

About RAC2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,225,270-37,244,269 (from NCBI)

This gene has 8 transcripts (splice variants), 235 orthologues, 22 paralogues and is associated with 4 phenotypes. Biased expression in lymph node (RPKM 157.7), bone marrow (RPKM 130.6) and 9 other tissues.

Summary

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of Reactive Oxygen Species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

RAC2 Products(1)

mRNA	Protein	Name
NM_002872.5	NP_002863.1	ras-related C3 botulinum toxin substrate 2

RAC2 Protein Structure

Ras

0
100
192 a.a.

Protein Preferred Names

Protein Names

ras-related C3 botulinum toxin substrate 2

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)

Recombinant RAC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74607	RAC2 Protein, Human (His)	P15153 (M1-C189)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

Neutrophil Immunodeficiency Syndrome	IMD73A
Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis	Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis
Rac 2 Deficiency

Immunodeficiency 73b With Defective Neutrophil Chemotaxis And Lymphopenia

IMD73B

Immunodeficiency, Type 73b, With Defective Neutrophil Chemotaxis And Lymphopenia

Immunodeficiency 73c With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia

IMD73C

Lymphopenia

Lymphocytopenia

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Combined T And B Cell Immunodeficiency

Cellulitis

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Systemic Mastocytosis

Systemic Mast Cell Disease	Systemic Tissue Mast Cell Disease
Mastocytosis, Systemic	Smcd - Systemic Mast Cell Disease
Smcd	Mast Cell Disease, Systemic
Systemic Mast-Cell Disease	Systemic Mastocytoses
Mastocytosis Systemic	Corneal Dystrophy, Subepithelial Mucinous
Smcd - [Systemic Mast Cell Disease]

Deafness, Autosomal Recessive 104

DFNB104	Autosomal Recessive Nonsyndromic Deafness 104
Autosomal Recessive Deafness 104	Deafness, Autosomal Recessive, 104
Deafness, Autosomal Recessive, Type 104

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency	Leukocyte Adhesion Deficiency 1
LAD1	Lad
Lymphocyte Function-Associated Antigen 1 Immunodeficiency	Leukocyte Adhesion Deficiency Type I
Leukocyte Adhesion Deficiency Type 1	Linear Iga Bullous Dermatosis
Linear Iga Dermatosis	Leukocyte-Adhesion Deficiency Syndrome
Lfa1 Immunodeficiency	Congenital Leukocyte Adherence Deficiency
Lad-I	Linear Iga Disease
Leukocyte Adhesion Deficiency Syndrome	Lad 1
Lfa 1 Immunodeficiency	Linear Immunoglobulin A Dermatosis
Leucocyte Adhesion Deficiency Type 1	Leukocyte Adhesion Molecule Deficiency Type 1

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Whim Syndrome 1

Whim Syndrome	Whims
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis	WHIMS1
Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome	Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1
Myelokathexis, Isolated	Wilm
Warts-Infections-Leukopenia-Myelokatexis Syndrome	Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-113849	MLS-573151	Inhibitor	99.74%	Unkown
HY-RS11592	RAC2 Human Pre-designed siRNA Set A		/	Unkown
HY-W051624S	(Rac)-2-Aminothiazoline-4-carboxylic acid-13C,15N2		/	Unkown
HY-W010590S	(Rac)-2-Aminobutyric acid-d3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAC2	VGNC	VGNC:98432
Mus musculus	RAC2	MGD	MGI:97846
Felis catus	RAC2	VGNC	VGNC:69209
Rattus norvegicus	RAC2	RGD	RGD:1307568
Canis familiaris	RAC2	VGNC	VGNC:49610
Bos taurus	RAC2	VGNC	VGNC:49061
Others	RAC2	NCBI

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