TFF3 - trefoil factor 3 Gene

Homo sapiens

Also known as ITF; P1B; TFI

Gene ID: 7033 | Gene type: protein coding

About TFF3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,311,667-42,315,409 (from NCBI)

This gene has 3 transcripts (splice variants), 92 orthologues and 2 paralogues. Biased expression in colon (RPKM 367.8), thyroid (RPKM 187.9) and 4 other tissues.

Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF3 Products(1)

mRNA	Protein	Name
NM_003226.4	NP_003217.4	trefoil factor 3 precursor

TFF3 Protein Structure

Trefoil

0
94 a.a.

Protein Preferred Names

Protein Names

trefoil factor 3

polypeptide P1.B

Recombinant TFF3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7295	TFF3 Protein, Human	Q07654 (E22-F80)	≥95%
HY-P74529	TFF3 Protein, Human (HEK293, His)	Q07654 (E22-F80)	≥95%
HY-P700523	TFF3 Protein, Human (P. pastoris, His)	Q07654 (L29-V80)	≥95%

Related Diseases

Diseases

Alias

Middle Cranial Fossa Meningioma

Meningioma Of The Middle Cranial Fossa

Neurilemmoma Of The Fifth Cranial Nerve

Trigeminal Schwannoma

Trigeminal Neurilemmoma

Trigeminal Nerve Neoplasm

Neoplasm Of Trigeminal Nerve

Tumor Of Trigeminal Nerve

Otosalpingitis

Eustachian Salpingitis	Eustachian Tube Salpingitis
Rhinosalpingitis	Tubotympanitis
Eustachian Tube Inflammation	Salpingitis Of Ear

Viral Esophagitis

Eustachian Tube Disease

Eustachian Tube Disorder	Auditory Tube Disorder
Disease Of Eustachian Tube	Eustachian Tube Dysfunction
Et- [Eustachian Tube Disorder]	Etd - [Eustachian Tube Dysfunction]

Medullary Colon Carcinoma

Non-Suppurative Otitis Media

Nonsuppurative Otitis Media

Colitis

Follicular Adenoma

Follicular Adenoma Of The Thyroid Gland	Thyroid Follicular Adenoma
Adenoma Follicular	Follicular Thyroid Adenoma
Thyroid Gland Follicular Adenoma

Alcoholic Psychosis

Psychoses, Alcoholic

Alcoholic Psychoses

Malignant Otitis Externa

Necrotising Otitis Externa

Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Enterocolitis

Inflammatory Bowel Disease 24

IBD24

Thyroid Cancer, Nonmedullary, 2

Thyroid Carcinoma, Follicular	Follicular Thyroid Carcinoma
NMTC2	Thyroid Cancer, Follicular
Thyroid Carcinoma, Follicular, Somatic	Ftc
Thyroid Cancer, Non-Medullary, 2	Thyroid Follicular Carcinoma
Follicular Thyroid Cancer	Cancer, Thyroid, Nonmedullary, Type 2
Thyroid Gland Adenocarcinoma	Follicular Carcinoma Of Unspecified Site
Moderately Differentiated Follicular Carcinoma Of Thyroid Gland	Pure Follicle Carcinoma Of Thyroid Gland
Pure Follicle Follicular Carcinoma Of Unspecified Site	Pure Follicular Carcinoma Of Thyroid Gland
Trabecular Follicular Carcinoma Of Thyroid Gland	Trabecular Follicular Carcinoma Of Unspecified Site
Well Differentiated Follicular Carcinoma Of Unspecified Site	Well Differentiated Follicular Carcinoma Of Thyroid Gland

Alcohol-Induced Mental Disorder

Psychoses, Alcoholic

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Epidermolysis Bullosa Simplex 5b, With Muscular Dystrophy

Epidermolysis Bullosa Simplex With Muscular Dystrophy	Md-Ebs
Epidermolysis Bullosa Simplex And Limb-Girdle Muscular Dystrophy	EBS5B
Ebsmd	Mdebs
Limb-Girdle Muscular Dystrophy With Epidermolysis Bullosa Simplex	Ebs-Md
Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy	Epidermolysa Bullosa Simplex With Muscular Dystrophy
Epidermolysis Bullosa Simplex - Limb Girdle Muscular Dystrophy	Ebs With Muscular Dystrophy
Muscular Dystrophy With Epidermolysis Bullosa Simplex	Epidermolysa Bullosa Simplex, With Muscular Dystrophy

Esophagus Adenocarcinoma

Esophageal Adenocarcinoma	Oesophageal Adenocarcinoma
Adenocarcinoma Of Esophagus	Adenocarcinoma Of The Esophagus

Sphenoid Sinusitis

Sphenoidal Sinusitis

Petrous Apex Meningioma

Meningioma Of The Petrous Ridge

Tremor, Hereditary Essential, 2

ETM2	Essential Tremor 2
Essential Tremor, Hereditary, 2	Hereditary Essential Tremor 2
Tremor Hereditary Essential, 2

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma	Follicular Adenocarcinoma
Follicular Adenocarcinoma, Well Differentiated	Follicular Carcinoma
Thyroid Adenocarcinoma	Adenocarcinoma, Follicular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139065	AMPC	Inhibitor	99.87%	Unkown
HY-RS14424	TFF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TFF3	VGNC	VGNC:35792
Macaca mulatta	TFF3	VGNC	VGNC:108447
Rattus norvegicus	TFF3	RGD	RGD:3847
Canis familiaris	TFF3	VGNC	VGNC:47298
Mus musculus	TFF3	MGD	MGI:104638
Felis catus	TFF3	VGNC	VGNC:66121
Others	TFF3	NCBI

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