2. Gene
  3. UCHL3 - ubiquitin C-terminal hydrolase L3 Gene

UCHL3 - ubiquitin C-terminal hydrolase L3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UCH-L3

Gene ID: 7347 | Gene type: protein coding

About UCHL3

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,549,502-75,606,020 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.1), testis (RPKM 4.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the deubiquitinating Enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

UCHL3 Products(2)

mRNA Protein Name
NM_001270952.2 NP_001257881.1 ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1
NM_006002.5 NP_005993.1 ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

UCHL3 Protein Structure

Peptidase_C12

Peptidase_C12: Ubiquitin carboxyl-terminal hydrolase, family 1 (5 - 215)

  • 0
  • 100
  • 200
  • 230 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase isozyme L3

testicular tissue protein Li 221

Recombinant UCHL3 Proteins

Cat. No. Product Name Accession Purity
HY-P71115 UCHL3 Protein, Human (His) P15374 (M1-A230) ≥95%

Related Diseases

Diseases Alias
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18637 LDN-57444 98.23% Unkown
HY-133118 6RK73 Inhibitor 99.52% Unkown
HY-18638 TCID Inhibitor 99.87% Unkown
HY-149230 USP28-IN-4 Inhibitor 99.35% Unkown
HY-149228 USP28-IN-2 Inhibitor / Unkown
HY-149229 USP28-IN-3 Inhibitor / Unkown
HY-RS15401 UCHL3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UCHL3 VGNC VGNC:78706
Bos taurus UCHL3 VGNC VGNC:36632
Rattus norvegicus UCHL3 RGD RGD:1561196
Mus musculus UCHL3 MGD MGI:1355274
Felis catus UCHL3 VGNC VGNC:66796
Canis familiaris UCHL3 VGNC VGNC:48104
Others UCHL3 NCBI