MPIG6B - megakaryocyte and platelet inhibitory receptor G6b Gene

Homo sapiens

Also known as G6b; NG31; G6b-B; THAMY; C6orf25

Gene ID: 80739 | Gene type: protein coding

About MPIG6B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,720,296-31,726,714 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 89 orthologues and is associated with 1 phenotype. Broad expression in skin (RPKM 2.2), bone marrow (RPKM 1.5) and 14 other tissues.

Summary

This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MPIG6B Products(6)

mRNA	Protein	Name
NM_025260.4	NP_079536.2	megakaryocyte and platelet inhibitory receptor G6b isoform G6b-A precursor
NM_138272.3	NP_612116.1	megakaryocyte and platelet inhibitory receptor G6b isoform G6b-B precursor
NM_138273.3	NP_612117.1	megakaryocyte and platelet inhibitory receptor G6b isoform G6b-C precursor
NM_138274.3	NP_612118.1	megakaryocyte and platelet inhibitory receptor G6b isoform G6b-D precursor
NM_138275.3	NP_612119.1	megakaryocyte and platelet inhibitory receptor G6b isoform G6b-E precursor
NM_138277.3	NP_612121.1	megakaryocyte and platelet inhibitory receptor G6b isoform G6b-G precursor

MPIG6B Protein Structure

G6B

0
100
200
241 a.a.

Protein Preferred Names

Protein Names

megakaryocyte and platelet inhibitory receptor G6b

immunoglobulin receptor

Recombinant MPIG6B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75784	G6B Protein, Human (HEK293, Fc)	O95866 (M1-Q146)	≥95%
HY-P75785	G6B Protein, Human (HEK293, His)	O95866/NP_612116.1 (N18-Q142)	≥95%

Related Diseases

Diseases

Alias

Thrombocytopenia, Anemia, And Myelofibrosis

THAMY

Myelofibrosis

Primary Myelofibrosis	Agnogenic Myeloid Metaplasia
Idiopathic Myelofibrosis	Myeloid Metaplasia
Myelofibrosis With Myeloid Metaplasia	Osteomyelofibrosis
Megakaryocytic Myelosclerosis	Myelosclerosis
Chronic Idiopathic Myelofibrosis	Myelofibrosis, Idiopathic
Myelofibrosis With Myeloid Metaplasia, Somatic	Myelofibrosis, Somatic
Aleukemic Myelosis	Bone Marrow Fibrosis
MYELOF	MMM
Agnogenic Myeloid Metaplasia With Myelofibrosis	Ammm
Myelosclerosis With Myeloid Metaplasia	Myelofibrosis Nos

Gray Platelet Syndrome

Platelet Alpha-Granule Deficiency	GPS
Bdplt4	Bleeding Disorder, Platelet-Type, 4
Grey Platelet Syndrome	Platelet-Type Bleeding Disorder 4
Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins	Deficient Alpha Granule Syndrome
Platelet Alpha Granule Deficiency	Platelet Granule Defect
Alpha Storage Pool Deficiency	Bleeding Disorder Platelet-Type 4

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Pseudo-Von Willebrand Disease

Bdplt3	Von Willebrand Disease, Platelet-Type
VWDP	Platelet-Type Bleeding Disorder 3
Platelet Type-Von Willebrand Disease	Pt-Vwd
Von Willebrand Disease Platelet-Type	Von Willebrand Disease, Platelet Type
Pseudo Von Willebrand Disease	Bleeding Disorder, Platelet-Type, 3
Pseudo-Von Willebrand Disease Type 2b	Bleeding Disorder Platelet-Type 3
Pseudo-Vwd

Pancytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08615	MPIG6B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MPIG6B	RGD	RGD:1303269
Bos taurus	MPIG6B	VGNC	VGNC:31577
Felis catus	MPIG6B	VGNC	VGNC:63572
Mus musculus	MPIG6B	MGD	MGI:2146995
Macaca mulatta	MPIG6B	VGNC	VGNC:74736
Canis familiaris	MPIG6B	VGNC	VGNC:49683
Others	MPIG6B	NCBI

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