GSK1614343

Cat. No.: HY-113906: FAQs
Data Sheet Handling Instructions

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GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC₅₀ value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models.

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GSK1614343 Chemical Structure

CAS No. : 1092076-04-4

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Other Forms of GSK1614343:

(αR,8aS)-GSK1614343 In-stock

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

487.44

Formula

C₂₂H₂₃F₆N₅O

CAS No.

1092076-04-4

SMILES

O=C([C@@H](C1=CC=CN=C1)N2C[C@@]3([H])CCCN3CC2)NNC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (205.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0515 mL	10.2577 mL	20.5153 mL
5 mM	0.4103 mL	2.0515 mL	4.1031 mL
10 mM	0.2052 mL	1.0258 mL	2.0515 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Perdonà E, et al. Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors. Eur J Pharmacol. 2011;650(1):178-183. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0515 mL	10.2577 mL	20.5153 mL	51.2884 mL
	5 mM	0.4103 mL	2.0515 mL	4.1031 mL	10.2577 mL
	10 mM	0.2052 mL	1.0258 mL	2.0515 mL	5.1288 mL
	15 mM	0.1368 mL	0.6838 mL	1.3677 mL	3.4192 mL
	20 mM	0.1026 mL	0.5129 mL	1.0258 mL	2.5644 mL
	25 mM	0.0821 mL	0.4103 mL	0.8206 mL	2.0515 mL
	30 mM	0.0684 mL	0.3419 mL	0.6838 mL	1.7096 mL
	40 mM	0.0513 mL	0.2564 mL	0.5129 mL	1.2822 mL
	50 mM	0.0410 mL	0.2052 mL	0.4103 mL	1.0258 mL
	60 mM	0.0342 mL	0.1710 mL	0.3419 mL	0.8548 mL
	80 mM	0.0256 mL	0.1282 mL	0.2564 mL	0.6411 mL
	100 mM	0.0205 mL	0.1026 mL	0.2052 mL	0.5129 mL

GSK1614343 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK16143431092076-04-4GSK 1614343GSK-1614343GHSRGrowth hormone secretagogue receptorGhrelin receptorGHS1acalcium responseghrelintoolInhibitorinhibitorinhibit

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