H-Asn(glcnac-beta-D)-OH

Name: H-Asn(glcnac-beta-D)-OH
Brand: MedChemExpress
SKU: HY-N9446
Rating: 4.5 (1 reviews)

Cat. No.: HY-N9446 Purity: 98.65%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

H-Asn(glcnac-beta-D)-OH is an endogenous metabolite present in Urine that can be used for the research of NGLY1-CDDG.

For research use only. We do not sell to patients.

H-Asn(glcnac-beta-D)-OH Chemical Structure

CAS No. : 2776-93-4

Size	Price	Stock	Quantity
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

H-Asn(glcnac-beta-D)-OH is an endogenous metabolite present in Urine that can be used for the research of NGLY1-CDDG^[1]^[2].

In Vitro

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

335.31

Formula

C₁₂H₂₁N₃O₈

CAS No.

2776-93-4

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CC(N[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)NC(C)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (372.79 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9823 mL	14.9116 mL	29.8231 mL
5 mM	0.5965 mL	2.9823 mL	5.9646 mL
10 mM	0.2982 mL	1.4912 mL	2.9823 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.65%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (272 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720. [Content Brief]

[2]. Haijes HA, et al. Aspartylglycosamine is a biomarker for NGLY1-CDDG, a congenital disorder of deglycosylation. Mol Genet Metab. 2019 Aug;127(4):368-372. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9823 mL	14.9116 mL	29.8231 mL	74.5579 mL
	5 mM	0.5965 mL	2.9823 mL	5.9646 mL	14.9116 mL
	10 mM	0.2982 mL	1.4912 mL	2.9823 mL	7.4558 mL
	15 mM	0.1988 mL	0.9941 mL	1.9882 mL	4.9705 mL
	20 mM	0.1491 mL	0.7456 mL	1.4912 mL	3.7279 mL
	25 mM	0.1193 mL	0.5965 mL	1.1929 mL	2.9823 mL
	30 mM	0.0994 mL	0.4971 mL	0.9941 mL	2.4853 mL
	40 mM	0.0746 mL	0.3728 mL	0.7456 mL	1.8639 mL
	50 mM	0.0596 mL	0.2982 mL	0.5965 mL	1.4912 mL
	60 mM	0.0497 mL	0.2485 mL	0.4971 mL	1.2426 mL
	80 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9320 mL
	100 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.7456 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.