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H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation.

For research use only. We do not sell to patients.

H1PVAT Chemical Structure

H1PVAT Chemical Structure

CAS No. : 351438-49-8

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Based on 1 publication(s) in Google Scholar

H1PVAT Related Antibodies

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Description

H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation[1][2].

IC50 & Target

EC50: 10 nM (PV-1), 26 nM (PV-2), 218 nM (PV-3)[1]
In Vitro

H1PVAT (10-218 nM; 24-48 h) inhibits poliovirus strain Sabin replication in a dose-dependent manner, with EC50s of 10 nM (PV-1), 26 nM (PV-2) and 218 nM (PV-3), respectively[1].
H1PVAT (30 min prior to or 1 h after PV-1 infection; 7 h) inhibits an early stage of viral replication , and only H1PVAT is administered prior to infection results reduction (>99.9%) in intracellular viral RNA levels[1].
H1PVAT (50 μM; 2 min) protects PV against heat inactivation with the 50% thermal inactivation temperature increased to 52.6 ℃ and 50.8 ℃, which suggests a direct interaction between the viral capsid and H1PVAT[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

H1PVAT Related Antibodies
Molecular Weight

417.41

Formula

C19H14F3N5OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN2C(C(F)(F)F)CC(C3=CC=CS3)NC2=C1)NC4=CC=C(C#N)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 96.40%

COA (247 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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H1PVAT Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H1PVAT351438-49-8Otherspoliovirus replicationinactivated polio vaccineIPVVP1V-073pirodavir capsid-bindervirus-induced cytopathic effectCPEserotypesviral capsidheat inactivationInhibitorinhibitorinhibit

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H1PVAT
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HY-12349
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