2. GPCR/G Protein
  3. ICMT
  4. ICMT-IN-53

ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively.

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ICMT-IN-53 Chemical Structure

ICMT-IN-53 Chemical Structure

CAS No. : 1443253-17-5

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ICMT-IN-53 Related Antibodies

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Description

ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively[1].

IC50 & Target

IC50: 0.96 μM (ICMT)[1]
Molecular Weight

409.58

Formula

C26H36FN3
CAS No.
SMILES

FC1=C(C=CN=C1)C2=CC=C(N(CCCCCCCC)C=C3CN(CC)CC)C3=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ICMT-IN-53 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICMT-IN-531443253-17-5ICMTIsoprenylcysteine carboxyl methyltransferaseMelanomacancer cell metastasiscell proliferationRAS membrane localizationmislocalizationisoprenylcysteine carboxyl methyltransferaseInhibitorinhibitorinhibit

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