2. NF-κB
  3. IKK
  4. IKK2-IN-4

IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs.

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IKK2-IN-4 Chemical Structure

IKK2-IN-4 Chemical Structure

CAS No. : 354811-10-2

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500 μg USD 146 In-stock

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Based on 1 publication(s) in Google Scholar

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Description

IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1].

IC50 & Target[1]

IKK-2

25 nM (IC50)

Molecular Weight

261.30

Formula

C12H11N3O2S
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(C1=C(NC(N)=O)SC(C2=CC=CC=C2)=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (382.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8270 mL 19.1351 mL 38.2702 mL
5 mM 0.7654 mL 3.8270 mL 7.6540 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8270 mL 19.1351 mL 38.2702 mL 95.6755 mL
5 mM 0.7654 mL 3.8270 mL 7.6540 mL 19.1351 mL
10 mM 0.3827 mL 1.9135 mL 3.8270 mL 9.5675 mL
15 mM 0.2551 mL 1.2757 mL 2.5513 mL 6.3784 mL
20 mM 0.1914 mL 0.9568 mL 1.9135 mL 4.7838 mL
25 mM 0.1531 mL 0.7654 mL 1.5308 mL 3.8270 mL
30 mM 0.1276 mL 0.6378 mL 1.2757 mL 3.1892 mL
40 mM 0.0957 mL 0.4784 mL 0.9568 mL 2.3919 mL
50 mM 0.0765 mL 0.3827 mL 0.7654 mL 1.9135 mL
60 mM 0.0638 mL 0.3189 mL 0.6378 mL 1.5946 mL
80 mM 0.0478 mL 0.2392 mL 0.4784 mL 1.1959 mL
100 mM 0.0383 mL 0.1914 mL 0.3827 mL 0.9568 mL
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IKK2-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKK2-IN-4354811-10-2IKKIκB kinaseI kappa B kinaseLPSTNFαInhibitorinhibitorinhibit

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