2. Anti-infection
  3. Influenza Virus
  4. Influenza virus-IN-6

Influenza virus-IN-6 (Compound 35) is a potent influenza N-terminal domain of the polymerase acidic protein subunit (PAN) endonuclease inhibitor with an IC50 of 0.20 μM.

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Influenza virus-IN-6 Chemical Structure

Influenza virus-IN-6 Chemical Structure

CAS No. : 2919303-26-5

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Influenza virus-IN-6 Related Antibodies

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Description

Influenza virus-IN-6 (Compound 35) is a potent influenza N-terminal domain of the polymerase acidic protein subunit (PAN) endonuclease inhibitor with an IC50 of 0.20 μM[1].

IC50 & Target

IC50: 0.20 μM (PAN)[1]
KD: 56.02 nM (PAN)[1]
In Vitro

Influenza virus-IN-6 (Compound 35) (48 h) shows anti-influenza virus activity in MDCK cells with EC50s of 1.28 ± 0.35, 1.12 ± 0.65, 0.76 ± 0.11 and 0.43 ± 0.06 μM against H1N1, H5N1, H3N2 and Flu B, respectively[1].
Influenza virus-IN-6 (5-20 μM; 24 h) affects virus replication but not virus particles, cells, and adsorption[1].
Influenza virus-IN-6 (2.5-10 μM; 24 h) inhibits influenza viral polymerase activity[1].
Influenza virus-IN-6 displayed promising stability in mouse plasma, liver microsomes, and intestinal S9-UDPGA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza virus-IN-6 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDCK cells
Concentration: 5, 10 and 20 μM
Incubation Time: 24 h
Result: Decreased nucleoprotein (NP) and matrix protein 2 (M2).

RT-PCR[1]

Cell Line: MDCK cells
Concentration: 2.5, 5, 10 and 20 μM
Incubation Time: 24 h
Result: Decreased the expression of viral NP mRNA in a well-defined dose-dependent manner. Inhibited cRNA synthesis in a dose-dependent fashion.
In Vivo

Influenza virus-IN-6 (Compound 35) (7.5-30 mg/kg/d; i.p.; twice daily for 7 days) markedly protects mice from influenza virus infection[1].
Pharmacokinetic (PK) Profile In Vivo of Influenza virus-IN-6 (Compound 35) after a Single Dose in Rats In Vivo (n = 5)a[1]

parameter IV (2 mg/kg) PO (10 mg/kg) IP (15 mg/kg)
T1/2 (h) 0.33 ± 0.07 0.82 ± 0.16 1.07 ± 0.25
Tmax (h) NA 0.52 0.45
Cmax (ng/mL) 1586.55 ± 366.48 92.20 ± 36.25 889.52 ± 233.17
AUC0-t (h·ng/mL) 536.45 ± 58.72 164.30 ± 26.37 790.62 ± 188.31
CL (mL/min/kg) 53.76 ± 13.18 NA NA
F % NA 6.13% 29.50%

aIV represents intravenous injection, IP represents intraperitoneal injection, and PO represents the gastrointestinal route. T1/2 is the half-life of the compound exposure in plasma. Tmax is the time taken to reach the maximum concentration. Cmax represents the highest observed concentration. AUC (0–t) is the area under the curve. CL (mL/min/kg) is the clearance. F % is the percent bioavailability.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/C mice, H1N1 infection model[1]
Dosage: 0, 7.5, 15, and 30 mg/kg/d
Administration: Intraperitoneal injection, twice per day for 7 days
Result: Exhibited excellent anti-IAV activity in vivo at a dose of 30 mg/kg/d. Still showed potent antiviral activity in vivo, with a survival ratio of approximately 60% against lethal virus infection in mice at 15 mg/kg/d.
Animal Model: SD rats[1]
Dosage: 2, 10 or 15 mg/kg
Administration: IV, IP, or PO (Pharmacokinetic Analysis)
Result: Showed good pharmacokinetic profiles.
Molecular Weight

511.95

Formula

C27H26ClNO7
CAS No.
SMILES

CCCOC([C@@H]1CC2=CC(O)=C(C=C2[C@@H](N1C(C3=CC=CC=C3Cl)=O)CC4=CC=C(C(O)=C4)O)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Influenza virus-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza virus-IN-62919303-26-5Influenza VirusMDCKPAN endonucleaseH1N1H5N1H3N2Flu BInhibitorinhibitorinhibit

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